Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High fat diet induced insulin resistance and glucose intolerance are gender-specific in IGF-1R heterozygous mice.

Biochemical and biophysical research communications - 30 Sept 2011

Garg Neha, Thakur Sachin, McMahan C Alex, Adamo Martin L

Abstract excerpt

Interactions between genes and environment play a critical role in the pathogenesis of type 2 diabetes. Low birth weight, due to genetic and environmental variables affecting fetal growth, is associated with increased susceptibility to the development of type 2 diabetes and metabolic disorders in adulthood. Clinical studies have shown that polymorphisms in the Insulin-like growth factor 1 (IGF-1) gene or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Glucose
Share to CD36 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diet, High-Fat

Share to Dietary Fats

Share to Glucose Intolerance

Share to Glucose Tolerance Test

Share to Insulin Resistance

Share to Receptor, IGF Type 1

Source

Open in PubMed Open full text

Identifiers

PMID: 21910970
DOI: 10.1016/j.bbrc.2011.08.123
PMCID: PMC3185216

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High fat diet induced insulin resistance and glucose intolerance are gender-specific in IGF-1R heterozygous mice.PMID 21910970Read ↗

IGF-1 receptor haploinsufficiency leads to age-dependent development of metabolic syndrome.Semantic proximity Read ↗

Early-life Programming of Type 2 Diabetes Mellitus: Understanding the Association between Epigenetics/Genetics and Environmental FactorsSemantic proximity Read ↗

Haploinsufficiency in the PPARalpha and LDL receptor genes leads to gender- and age-specific obesity and hyperinsulinemia.Semantic proximity Read ↗

The Effects of High-Fat Diet Exposure In Utero on the Obesogenic and Diabetogenic Traits Through Epigenetic Changes in Adiponectin and Leptin Gene Expression for Multiple Generations in Female MiceSemantic proximity Read ↗

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice.Semantic proximity Read ↗

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r).Semantic proximity Read ↗

Maternal Obesity Has Little Effect on the Immediate Offspring but Impacts on the Next GenerationSemantic proximity Read ↗

Sex differences in transgenerational alterations of growth and metabolism in progeny (F2) of female offspring (F1) of rats fed a low protein diet during pregnancy and lactationSemantic proximity Read ↗

Knockout Mice Challenge our Concepts of Glucose Homeostasis and the Pathogenesis of DiabetesSemantic proximity Read ↗

[Interaction between environment and genetic background in type 2 diabetes: lessons from animal models].Semantic proximity Read ↗

Intergenerational Transmission of Glucose Intolerance and Obesity by In Utero Undernutrition in MiceSemantic proximity Read ↗

Maternal High-Fat Diet Alters Fetal Autonomic Activity Independently of Leptin Receptor Genotype in High-Risk Mouse Models of Type 2 Diabetes Mellitus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.