Article
miR-219 Cooperates with miR-338 in Myelination and Promotes Myelin Repair in the CNS.
Developmental cell - 27 Mar 2017
Wang Haibo, Moyano Ana Lis, Ma Zhangyan, Deng Yaqi, Lin Yifeng, Zhao Chuntao, Zhang Liguo, Jiang Minqing, He Xuelian, Ma Zhixing, Lu Fanghui, Xin Mei, Zhou Wenhao, Yoon Sung Ok, Bongarzone Ernesto R, Lu Q Richard
Abstract excerpt
A lack of sufficient oligodendrocyte myelination contributes to remyelination failure in demyelinating disorders. miRNAs have been implicated in oligodendrogenesis; however, their functions in myelin regeneration remained elusive. Through developmentally regulated targeted mutagenesis, we demonstrate that miR-219 alleles are critical for CNS myelination and remyelination after injury. Further deletion of miR-338...
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