Article
miR-23 regulation of lamin B1 is crucial for oligodendrocyte development and myelination.
Disease models & mechanisms - 1 Jan 2000
Lin Shu-Ting, Fu Ying-Hui
Abstract excerpt
Duplication of the gene encoding lamin B1 (LMNB1) with increased mRNA and protein levels has been shown to cause severe myelin loss in the brains of adult-onset autosomal dominant leukodystrophy patients. Similar to many neurodegenerative disorders, patients with adult-onset autosomal dominant leukodystrophy are phenotypically normal until adulthood and the defect is specific to the central nervous system despite...
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