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Article

Endogenously Expressed IL-4Rα Promotes the Malignant Phenotype of Human Pancreatic Cancer In Vitro and In Vivo.

International journal of molecular sciences - 28 Mar 2017

Traub Benno, Sun Lie, Ma Yongsu, Xu Pengfei, Lemke Johannes, Paschke Stephan, Henne-Bruns Doris, Knippschild Uwe, Kornmann Marko

Abstract excerpt

Exogenous interleukin-4 (IL-4) has been demonstrated to affect the growth of different human malignancies including pancreatic cancer cells. The aim of our study was to determine the role of endogenously expressed IL-4-receptor-α-chain (IL-4Rα) in pancreatic cancer cells. IL-4Rα-suppression was achieved by generating Capan-1 cells stably expressing shRNA targeting IL-4Rα. The malignant phenotype was characterized...

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Identifiers

PMID: 28350325
DOI: 10.3390/ijms18040716
PMCID: PMC5412302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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