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Article

FOXC1 plays a crucial role in the growth of pancreatic cancer

4 Jul 2018

Abstract excerpt

IGF-1R signaling controls various vital cellular functions and this signaling is deregulated in many cancers, including pancreatic cancer. Several efforts have mainly focused on inhibiting the IGF-1R signaling cascade. The outcomes of these focused preclinical studies have been positive, whereas clinical trials of IGF-1R inhibitors in pancreatic cancer have failed, raising the questions about this therapeutic...

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PMID: 29976975
DOI: 10.1038/s41389-018-0061-7

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