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Article

Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells.

Oncogene - 9 Oct 2003

Duda Dan G, Sunamura Makoto, Lefter Liviu P, Furukawa Toru, Yokoyama Tadaaki, Yatsuoka Toshimasa, Abe Tadayoshi, Inoue Hiroko, Motoi Fuyuhiko, Egawa Shin-ichi, Matsuno Seiki, Horii Akira

Abstract excerpt

SMAD4 is a critical cofactor in signal transduction pathways activated in response to transforming growth factor-beta (TGF-beta)-related ligands, regulating cell growth and differentiation. The roles played by SMAD4 inactivation in tumours highlighted it as a tumour-suppressor gene. However, restoration of the TGF-beta antiproliferative pathway following SMAD4 gene transfer in null-tumour cell lines is...

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Source

Identifiers

PMID: 14534532
DOI: 10.1038/sj.onc.1206751

Genes

SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells.PMID 14534532Read ↗

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