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Article

Bonobos Maintain Immune System Diversity with Three Functional Types of MHC-B.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2017

Wroblewski Emily E, Guethlein Lisbeth A, Norman Paul J, Li Yingying, Shaw Christiana M, Han Alex S, Ndjango Jean-Bosco N, Ahuka-Mundeke Steve, Georgiev Alexander V, Peeters Martine, Hahn Beatrice H, Parham Peter

Abstract excerpt

Fast-evolving MHC class I polymorphism serves to diversify NK cell and CD8 T cell responses in individuals, families, and populations. Because only chimpanzee and bonobo have strict orthologs of all HLA class I, their study gives unique perspectives on the human condition. We defined polymorphism of Papa-B, the bonobo ortholog of HLA-B, for six wild bonobo populations. Sequences for Papa-B exon 2 and 3 were...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 28348269
DOI: 10.4049/jimmunol.1601955
PMCID: PMC5469624

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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