Chimpanzee MHC class I A locus alleles are related to only one of the six families of human A locus alleles.

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Article

Chimpanzee MHC class I A locus alleles are related to only one of the six families of human A locus alleles.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1995

McAdam S N, Boyson J E, Liu X, Garber T L, Hughes A L, Bontrop R E, Watkins D I

Abstract excerpt

There are nearly 50 alleles at the highly polymorphic HLA-A class I locus that fall into six distinct families. To determine the allelic repertoire and the mechanism of generation of diversity of the A locus in primates we have analyzed A locus alleles from 28 apparently unrelated chimpanzees (Pan troglodytes) and bonobos (Pan paniscus). We have, therefore, compared the sequences of 19 HLA-A homologues from...

Topics

Alleles
Amino Acid Sequence
Animals
Cloning, Molecular
DNA
DNA Primers
Genetic Variation
HLA-A Antigens
Histocompatibility Antigens Class I
Hominidae
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Pan troglodytes

Polymerase Chain Reaction

Polymorphism, Genetic

Sequence Homology, Amino Acid

Sequence Homology, Nucleic Acid

Species Specificity

Source

Open in PubMed

Identifiers

PMID: 7759878

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7759878-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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