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Article

Signature Patterns of MHC Diversity in Three Gombe Communities of Wild Chimpanzees Reflect Fitness in Reproduction and Immune Defense against SIVcpz.

PLoS biology - 1 May 2015

Wroblewski Emily E, Norman Paul J, Guethlein Lisbeth A, Rudicell Rebecca S, Ramirez Miguel A, Li Yingying, Hahn Beatrice H, Pusey Anne E, Parham Peter

Abstract excerpt

Major histocompatibility complex (MHC) class I molecules determine immune responses to viral infections. These polymorphic cell-surface glycoproteins bind peptide antigens, forming ligands for cytotoxic T and natural killer cell receptors. Under pressure from rapidly evolving viruses, hominoid MHC class I molecules also evolve rapidly, becoming diverse and species-specific. Little is known of the impact of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26020813
DOI: 10.1371/journal.pbio.1002144
PMCID: PMC4447270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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