Article
Rare variants in fox-1 homolog A (RBFOX1) are associated with lower blood pressure.
PLoS genetics - 1 Mar 2017
He Karen Y, Wang Heming, Cade Brian E, Nandakumar Priyanka, Giri Ayush, Ware Erin B, Haessler Jeffrey, Liang Jingjing, Smith Jennifer A, Franceschini Nora, Le Thu H, Kooperberg Charles, Edwards Todd L, Kardia Sharon L R, Lin Xihong, Chakravarti Aravinda, Redline Susan, Zhu Xiaofeng
Abstract excerpt
Many large genome-wide association studies (GWAS) have identified common blood pressure (BP) variants. However, most of the identified BP variants do not overlap with the linkage evidence observed from family studies. We thus hypothesize that multiple rare variants contribute to the observed linkage evidence. We performed linkage analysis using 517 individuals in 130 European families from the Cleveland Family...
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