Article
Rare coding variants in RCN3 are associated with blood pressure.
BMC genomics - 19 Feb 2022
He Karen Y, Kelly Tanika N, Wang Heming, Liang Jingjing, Zhu Luke, Cade Brian E, Assimes Themistocles L, Becker Lewis C, Beitelshees Amber L, Bielak Lawrence F, Bress Adam P, Brody Jennifer A, Chang Yen-Pei Christy, Chang Yi-Cheng, de Vries Paul S, Duggirala Ravindranath, Fox Ervin R, Franceschini Nora, Furniss Anna L, Gao Yan, Guo Xiuqing, Haessler Jeffrey, Hung Yi-Jen, Hwang Shih-Jen, Irvin Marguerite Ryan, Kalyani Rita R, Liu Ching-Ti, Liu Chunyu, Martin Lisa Warsinger, Montasser May E, Muntner Paul M, Mwasongwe Stanford, Naseri Take, Palmas Walter, Reupena Muagututi'a Sefuiva, Rice Kenneth M, Sheu Wayne H-H, Shimbo Daichi, Smith Jennifer A, Snively Beverly M, Yanek Lisa R, Zhao Wei, Blangero John, Boerwinkle Eric, Chen Yii-Der Ida, Correa Adolfo, Cupples L Adrienne, Curran Joanne E, Fornage Myriam, He Jiang, Hou Lifang, Kaplan Robert C, Kardia Sharon L R, Kenny Eimear E, Kooperberg Charles, Lloyd-Jones Donald, Loos Ruth J F, Mathias Rasika A, McGarvey Stephen T, Mitchell Braxton D, North Kari E, Peyser Patricia A, Psaty Bruce M, Raffield Laura M, Rao D C, Redline Susan, Reiner Alex P, Rich Stephen S, Rotter Jerome I, Taylor Kent D, Tracy Russell, Vasan Ramachandran S, Morrison Alanna C, Levy Daniel, Chakravarti Aravinda, Arnett Donna K, Zhu Xiaofeng
Abstract excerpt
BACKGROUND: While large genome-wide association studies have identified nearly one thousand loci associated with variation in blood pressure, rare variant identification is still a challenge. In family-based cohorts, genome-wide linkage scans have been successful in identifying rare genetic variants for blood pressure. This study aims to identify low frequency and rare genetic variants within previously reported...
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