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Article

Genetic effect of MTHFR C677T polymorphism on the structural covariance network and white-matter integrity in Alzheimer's disease.

Human brain mapping - 1 Jun 2017

Chang Yu-Tzu, Hsu Shih-Wei, Tsai Shih-Jen, Chang Ya-Ting, Huang Chi-Wei, Liu Mu-En, Chen Nai-Ching, Chang Wen-Neng, Hsu Jung-Lung, Lee Chen-Chang, Chang Chiung-Chih

Abstract excerpt

The 677 C to T transition in the MTHFR gene is a genetic determinant for hyperhomocysteinemia. We investigated whether this polymorphism modulates gray matter (GM) structural covariance networks independently of white-matter integrity in patients with Alzheimer's disease (AD). GM structural covariance networks were constructed by 3D T1-magnetic resonance imaging and seed-based analysis. The patients were divided...

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Identifiers

PMID: 28342207
DOI: 10.1002/hbm.23572
PMCID: PMC6866732

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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