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Article

Overexpression of exogenous kidney-specific Ngal attenuates progressive cyst development and prolongs lifespan in a murine model of polycystic kidney disease.

Kidney international - 1 Feb 2017

Wang Ellian, Chiou Yuan-Yow, Jeng Wen-Yih, Lin Hsiu-Kuan, Lin Hsi-Hui, Chin Hsian-Jean, Leo Wang Chi-Kuang, Yu Shang-Shiuan, Tsai Shih-Chieh, Chiang Chih-Ying, Cheng Po-Hao, Lin Hong-Jie, Jiang Si-Tse, Chiu Sou-Tyau, Hsieh-Li Hsiu Mei

Abstract excerpt

Neutrophil gelatinase-associated lipocalin (Ngal) is a biomarker for acute and chronic renal injuries, including polycystic kidney disease (PKD). However, the effect of Ngal on PKD progression remains unexplored. To study this, we generated 3 strains of mice with different expression levels of Ngal within an established PKD model (Pkd1L3/L3): Pkd1L3/L3 (with endogenous Ngal), Pkd1L3/L3; NgalTg/Tg (with endogenous...

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PMID: 28341240
DOI: 10.1016/j.kint.2016.09.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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