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Article

Attenuation of accelerated renal cystogenesis in Pkd1 mice by renin-angiotensin system blockade.

American journal of physiology. Renal physiology - 1 Feb 2018

Fitzgibbon Wayne R, Dang Yujing, Bunni Marlene A, Baicu Catalin F, Zile Michael R, Mullick Adam E, Saigusa Takamitsu

Abstract excerpt

The intrarenal renin angiotensin system (RAS) is activated in polycystic kidney disease. We have recently shown in the Pkd1 mouse that Gen 2 antisense oligonucleotide (ASO), which suppresses angiotensinogen (Agt) synthesis, is efficacious in slowing kidney cyst formation compared with lisinopril. The aim of this current study was to determine 1) if unilateral nephrectomy accelerates cystogenesis in Pkd1 mice (as...

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Identifiers

PMID: 29021226
DOI: 10.1152/ajprenal.00389.2017
PMCID: PMC5866454

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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