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Article

Role of scavenger receptors as damage-associated molecular pattern receptors in Toll-like receptor activation.

International immunology - 1 Feb 2017

Komai Kyoko, Shichita Takashi, Ito Minako, Kanamori Mitsuhiro, Chikuma Shunsuke, Yoshimura Akihiko

Abstract excerpt

Damage-associated molecular patterns (DAMPs) have been implicated in sterile inflammation in various tissue injuries. High-mobility group box 1 (HMGB1) is a representative DAMP, and has been shown to transmit signals through receptors for advanced glycation end products (RAGEs) and TLRs, including TLR2 and TLR4. HMGB1 does not, however, bind to TLRs with high affinity; therefore, the mechanism of HMGB1-mediated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28338748
DOI: 10.1093/intimm/dxx010

Genes

HMGB1
TLR4
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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