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Article

Scavenger receptor A1 participates in uptake of Leptospira interrogans serovar Autumnalis strain 56606v and inflammation in mouse macrophages.

Emerging microbes & infections - 1 Dec 2021

Wang Yanchun, Fan Xia, Du Lin, Liu Boyu, Xiao Haihan, Zhang Yan, Wu Yunqiang, Liu Fuli, Chang Yung-Fu, Guo Xiaokui, He Ping

Abstract excerpt

Leptospirosis, caused by pathogenic Leptospira species, has emerged as a widespread zoonotic disease worldwide. Macrophages mediate the elimination of pathogens through phagocytosis and cytokine production. Scavenger receptor A1 (SR-A1), one of the critical receptors mediating this process, plays a complicated role in innate immunity. However, the role of SR-A1 in the immune response against pathogenic Leptospira...

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Identifiers

PMID: 33929941
DOI: 10.1080/22221751.2021.1925160
PMCID: PMC8153709

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