Article
Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens.
Nature - 30 Mar 2017
Khodadoust Michael S, Olsson Niclas, Wagar Lisa E, Haabeth Ole A W, Chen Binbin, Swaminathan Kavya, Rawson Keith, Liu Chih Long, Steiner David, Lund Peder, Rao Samhita, Zhang Lichao, Marceau Caleb, Stehr Henning, Newman Aaron M, Czerwinski Debra K, Carlton Victoria E H, Moorhead Martin, Faham Malek, Kohrt Holbrook E, Carette Jan, Green Michael R, Davis Mark M, Levy Ronald, Elias Joshua E, Alizadeh Ash A
Abstract excerpt
Cancer somatic mutations can generate neoantigens that distinguish malignant from normal cells. However, the personalized identification and validation of neoantigens remains a major challenge. Here we discover neoantigens in human mantle-cell lymphomas by using an integrated genomic and proteomic strategy that interrogates tumour antigen peptides presented by major histocompatibility complex (MHC) class I and...
Topics
- Antigen Presentation
- Antigens, Neoplasm
- CD4-Positive T-Lymphocytes
- Cytotoxicity, Immunologic
- DNA Mutational Analysis
- Epitopes, T-Lymphocyte
- Exome
- Genomics