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Article

A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies

1 Sept 2014

Abstract excerpt

Neuroblastoma, a childhood cancer that originates from neural crest-derived cells, is the most common deadly solid tumor of infancy. Amplification of the MYCN oncogene, which occurs in approximately 20-25% of human neuroblastomas, is the most prominent genetic marker of high-stage disease. The availability of valid preclinical in vivo models is a prerequisite to develop novel targeted therapies. We here report on...

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PMID: 25174395
DOI: 10.1038/onc.2014.269

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