GPC2 provides prognostic value in pan-pediatric cancers and is associated with MYCN amplification in neuroblastoma：Bioinformatics Analysis and Validation

Abstract excerpt

<title>Abstract</title> <p>Background Glypican-2 (GPC2), a member of the GPC gene family, primarily functions in developing neural and thyroid cancer tissues, exerting influence on protein transduction, cellular proliferation and differentiation, as well as oncogenic signatures. GPC2 exhibits significant overexpression in the majority of neuroblastoma (NB) samples while remaining nearly undetectable in normal pe...

Topics

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• CAR-T cell therapy research
• Case-Control Studies
• Child
• East Asian People
• Genetic Predisposition to Disease
• Glypicans
• Neuroblastoma
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

6a432f61-e785-5ea6-8023-c2337f04c145

DOI

10.21203/rs.3.rs-5242931/v1