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Article

Elevated expression of DJ-1 (encoded by the human PARK7 gene) protects neuronal cells from sevoflurane-induced neurotoxicity.

Cell stress & chaperones - 1 Sept 2018

Zhang Yajie, Li Yu, Han Xuechang, Dong Xu, Yan Xiangbiao, Xing Qunzhi

Abstract excerpt

Sevoflurane, an inhaled ether general anesthetic agent, exerts a variety of neurotoxic effects, including oxidative stress, mitochondrial dysfunction, and neuronal apoptosis. However, the underlying molecular mechanisms remain to be elucidated. DJ-1 is a protein that exerts neuroprotective effects against different kinds of stress through multiple pathways. This study aimed to investigate the neuroprotective...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Deglycase DJ-1

Source

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Identifiers

PMID: 29728856
DOI: 10.1007/s12192-018-0904-3
PMCID: PMC6111095

Genes

PARK7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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