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Article

PilY1 Promotes Legionella pneumophila Infection of Human Lung Tissue Explants and Contributes to Bacterial Adhesion, Host Cell Invasion, and Twitching Motility.

Frontiers in cellular and infection microbiology - 1 Jan 2017

Hoppe Julia, Ünal Can M, Thiem Stefanie, Grimpe Louisa, Goldmann Torsten, Gaßler Nikolaus, Richter Matthias, Shevchuk Olga, Steinert Michael

Abstract excerpt

Legionnaires' disease is an acute fibrinopurulent pneumonia. During infection Legionella pneumophila adheres to the alveolar lining and replicates intracellularly within recruited macrophages. Here we provide a sequence and domain composition analysis of the L. pneumophila PilY1 protein, which has a high homology to PilY1 of Pseudomonas aeruginosa. PilY1 proteins of both pathogens contain a von Willebrand factor...

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Identifiers

PMID: 28326293
DOI: 10.3389/fcimb.2017.00063
PMCID: PMC5339237

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