Article
Systematic functional analysis reveals that a set of seven genes is involved in fine-tuning of the multiple functions mediated by type IV pili in Neisseria meningitidis.
Infection and immunity - 1 Jul 2010
Brown Daniel R, Helaine Sophie, Carbonnelle Etienne, Pelicic Vladimir
Abstract excerpt
Type IV pili (Tfp), which mediate multiple phenotypes ranging from adhesion to motility, are one of the most widespread virulence factors in bacteria. However, the molecular mechanisms of Tfp biogenesis and associated functions remain poorly understood. One of the underlying reasons is that the roles played by the numerous genes involved in Tfp biology are unclear because corresponding mutants have been studied...
Topics
- Bacterial Adhesion
- DNA, Bacterial
- Electrophoresis, Polyacrylamide Gel
- Enzyme-Linked Immunosorbent Assay
- Fimbriae Proteins
- Fimbriae, Bacterial
- Genes, Bacterial
- Humans
- Immunoblotting
- Mutation