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Article

Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes.

Proceedings of the National Academy of Sciences of the United States of America - 4 Apr 2017

Song Eun Suk, Jang HyeIn, Guo Hou-Fu, Juliano Maria A, Juliano Luiz, Morris Andrew J, Galperin Emilia, Rodgers David W, Hersh Louis B

Abstract excerpt

Insulin-degrading enzyme (IDE) hydrolyzes bioactive peptides, including insulin, amylin, and the amyloid β peptides. Polyanions activate IDE toward some substrates, yet an endogenous polyanion activator has not yet been identified. Here we report that inositol phosphates (InsPs) and phosphatdidylinositol phosphates (PtdInsPs) serve as activators of IDE. InsPs and PtdInsPs interact with the polyanion-binding site...

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Androstadienes
Chlorocebus aethiops
Endosomes
Inositol Phosphates
Insulysin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphatidylinositols

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PMID: 28325868
DOI: 10.1073/pnas.1613447114
PMCID: PMC5389272

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IDE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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