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Article

An Extended Polyanion Activation Surface in Insulin Degrading Enzyme.

PloS one - 1 Jan 2015

Song Eun Suk, Ozbil Mehmet, Zhang Tingting, Sheetz Michael, Lee David, Tran Danny, Li Sheng, Prabhakar Rajeev, Hersh Louis B, Rodgers David W

Abstract excerpt

Insulin degrading enzyme (IDE) is believed to be the major enzyme that metabolizes insulin and has been implicated in the degradation of a number of other bioactive peptides, including amyloid beta peptide (Aβ), glucagon, amylin, and atrial natriuretic peptide. IDE is activated toward some substrates by both peptides and polyanions/anions, possibly representing an important control mechanism and a potential...

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Identifiers

PMID: 26186535
DOI: 10.1371/journal.pone.0133114
PMCID: PMC4506039

Genes

IDE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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