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Article

Identification of the allosteric regulatory site of insulysin.

PloS one - 1 Jan 2011

Noinaj Nicholas, Bhasin Sonia K, Song Eun Suk, Scoggin Kirsten E, Juliano Maria A, Juliano Luiz, Hersh Louis B, Rodgers David W

Abstract excerpt

BACKGROUND: Insulin degrading enzyme (IDE) is responsible for the metabolism of insulin and plays a role in clearance of the Aβ peptide associated with Alzheimer's disease. Unlike most proteolytic enzymes, IDE, which consists of four structurally related domains and exists primarily as a dimer, exhibits allosteric kinetics, being activated by both small substrate peptides and polyphosphates such as ATP. PRINCIPAL...

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Identifiers

PMID: 21731629
DOI: 10.1371/journal.pone.0020864
PMCID: PMC3123307

Genes

IDE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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