Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Anion activation site of insulin-degrading enzyme.

The Journal of biological chemistry - 2 Jan 2012

Noinaj Nicholas, Song Eun Suk, Bhasin Sonia, Alper Benjamin J, Schmidt Walter K, Hersh Louis B, Rodgers David W

Abstract excerpt

Insulin-degrading enzyme (IDE) (insulysin) is a zinc metallopeptidase that metabolizes several bioactive peptides, including insulin and the amyloid β peptide. IDE is an unusual metallopeptidase in that it is allosterically activated by both small peptides and anions, such as ATP. Here, we report that the ATP-binding site is located on a portion of the substrate binding chamber wall arising largely from domain 4...

Topics

Join the communities discussing this publication.

Adenosine Triphosphate
Anions
Crystallography, X-Ray
Enzyme Activation
Insulysin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Intracellular Space

Protein Conformation

Source

Open in PubMed Open full text

Identifiers

PMID: 22049080
DOI: 10.1074/jbc.M111.264614
PMCID: PMC3249101

Genes

IDE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Anion activation site of insulin-degrading enzyme.PMID 22049080Read ↗

An Extended Polyanion Activation Surface in Insulin Degrading Enzyme.Semantic proximity Read ↗

Identification of the allosteric regulatory site of insulysin.Semantic proximity Read ↗

Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes.Semantic proximity Read ↗

Mixed dimers of insulin-degrading enzyme reveal a cis activation mechanism.Semantic proximity Read ↗

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones.Semantic proximity Read ↗

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in miceSemantic proximity Read ↗

Ligand binding shuttles thrombin along a continuum of zymogen- and proteinase-like states.Semantic proximity Read ↗

Ionic contacts at DnaK substrate binding domain involved in the allosteric regulation of lid dynamics.Semantic proximity Read ↗

Allosteric inhibition of the epithelial Na+ channel through peptide binding at peripheral finger and thumb domains.Semantic proximity Read ↗

Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions.Semantic proximity Read ↗

Inhibitor and ion binding sites on the gastric H,K-ATPase.Semantic proximity Read ↗

Probing the role of the chloride ion in the mechanism of human pancreatic alpha-amylase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.