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Article

A soluble peripherin/Rds C-terminal polypeptide promotes membrane fusion and changes conformation upon membrane association.

Experimental eye research - 1 Oct 2003

Boesze-Battaglia Kathleen, Goldberg Andrew F X, Dispoto Janice, Katragadda Madan, Cesarone Gregory, Albert Arlene D

Abstract excerpt

Photoreceptor rod cells contain a unique tetraspanin fusion protein known as peripherin/rds. This protein is important in membrane fusion events hypothesized to be essential to disk membrane morphogenesis and disk shedding. In vivo and in vitro fusogenic activity has been mapped to the C-terminal...

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PMID: 12957149
DOI: 10.1016/s0014-4835(03)00151-9
PMCID: PMC4732724

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12957149-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

A soluble peripherin/Rds C-terminal polypeptide promotes membrane fusion and changes conformation upon membrane association.PMID 12957149Read ↗

Deletional analysis of the rod photoreceptor cell peripherin/RDS carboxy-terminal region.Semantic proximity Read ↗

An inducible amphipathic helix within the intrinsically disordered C terminus can participate in membrane curvature generation by peripherin-2/rds.Semantic proximity Read ↗

Peripherin/rds Influences Membrane Vesicle MorphologySemantic proximity Read ↗

Role of the Second Intradiscal Loop of Peripherin/<i>rds </i>in Homo and Hetero AssociationsSemantic proximity Read ↗

Folding and subunit assembly of photoreceptor peripherin/rds is mediated by determinants within the extracellular/intradiskal EC2 domain: implications for heterogeneous molecular pathologies.Semantic proximity Read ↗

An intramembrane glutamic acid governs peripherin/rds function for photoreceptor disk morphogenesis.Semantic proximity Read ↗

The role of subunit assembly in peripherin-2 targeting to rod photoreceptor disk membranes and retinitis pigmentosa.Semantic proximity Read ↗

Molecular characterization of peripherin-2 and rom-1 mutants responsible for digenic retinitis pigmentosa.Semantic proximity Read ↗

Multistep peripherin-2/rds self-assembly drives membrane curvature for outer segment disk architecture and photoreceptor viabilitySemantic proximity Read ↗

The Role of Peripherin-2/ROM1 Complexes in Photoreceptor Outer Segment Disc Morphogenesis.Semantic proximity Read ↗

Expression and characterization of peripherin/rds-rom-1 complexes and mutants implicated in retinal degenerative diseases.Semantic proximity Read ↗

The R172W mutation in peripherin/rds causes a cone-rod dystrophy in transgenic miceSemantic proximity Read ↗

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