Article
Associations of Endothelin Polymorphisms and Aneurysm Size at Time of Rupture.
World neurosurgery - 1 Jun 2017
Hendrix Philipp, Foreman Paul M, Starke Robert M, Harrigan Mark R, Fisher Winfield S, Vyas Nilesh A, Lipsky Robert H, Lin Minkuan, Walters Beverly C, Tubbs R Shane, Shoja Mohammadali M, Pittet Jean-Francois, Mathru Mali, Griessenauer Christoph J
Abstract excerpt
BACKGROUND AND PURPOSE: Aneurysm size is an important risk factor for aneurysm rupture. The pathophysiologic mechanisms underlying aneurysm growth remain poorly understood. Endothelin signaling is critical for cerebrovascular blood flow regulation. The influence of endothelin single nucleotide polymorphisms (SNPs) on aneurysm size at the time of rupture has not been previously investigated. METHODS: Eight common...
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