Article
Sumoylation by Ubc9 regulates the stem cell compartment and structure and function of the intestinal epithelium in mice.
Gastroenterology - 1 Jan 2011
Demarque Maud D, Nacerddine Karim, Neyret-Kahn Hélène, Andrieux Alexandra, Danenberg Esther, Jouvion Grégory, Bomme Perrine, Hamard Ghislaine, Romagnolo Béatrice, Terris Benoît, Cumano Ana, Barker Nick, Clevers Hans, Dejean Anne
Abstract excerpt
BACKGROUND & AIMS: Small ubiquitin-like modifiers (SUMOs) are attached to other proteins to regulate their function (sumoylation). We investigated the role of Ubc9, which covalently attaches SUMOs to proteins, in the gastrointestinal tract of adult mice. METHODS: We investigated the effects of decreased sumoylation in adult mammals by generating mice with an inducible knockout (by injection of 4-hydroxytamoxifen)...
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