Animal models of Diamond-Blackfan anemia: updates and challenges.

Abstract excerpt

Diamond-Blackfan anemia (DBA) is a ribosomopathy that is characterized by macrocytic anemia, congenital malformations, and early onset during childhood. Genetic studies have demonstrated that most patients carry mutations in one of the 20 related genes, most of which encode ribosomal proteins (RP). Treatment of DBA includes corticosteroid therapy, chronic red blood cell transfusion, and other forms of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Ribosomal Proteins
• Share to Models, Animal
• Share to Mutation