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Recent advances in human stem cell-based modeling of Tuberous Sclerosis Complex

19 Feb 2020

Abstract excerpt

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by epilepsy, intellectual disability, and benign tumors of the brain, heart, skin, and kidney. Animal models have contributed to our understanding of normal and abnormal human brain development, but the construction of models that accurately recapitulate a human pathology remains challenging. Recent advances in stem cell biology with...

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PMID: 32075691
DOI: 10.1186/s13229-020-0320-2

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