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H3K9 dimethylation safeguards cancer cells against activation of the interferon pathway

18 Mar 2022

Abstract excerpt

Activation of interferon genes constitutes an important anticancer pathway able to restrict proliferation of cancer cells. Here, we demonstrate that the H3K9me3 histone methyltransferase (HMT) suppressor of variegation 3-9 homolog 1 (SUV39H1) is required for the proliferation of acute myeloid leukemia (AML) and find that its loss leads to activation of the interferon pathway. Mechanistically, we show that this...

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PMID: 35302840
DOI: 10.1126/sciadv.abf8627

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