Article
Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.
Nature medicine - 1 Feb 2001
Mäkinen T, Jussila L, Veikkola T, Karpanen T, Kettunen M I, Pulkkanen K J, Kauppinen R, Jackson D G, Kubo H, Nishikawa S, Ylä-Herttuala S, Alitalo K
Abstract excerpt
The lymphatic vasculature transports extravasated tissue fluid, macromolecules and cells back into the blood circulation. Recent reports have focused on the molecular mechanisms regulating the lymphatic vessels. Vascular endothelial growth factor (VEGF)-C and VEGF-D have been shown to stimulate lymphangiogenesis and their receptor, VEGFR-3, has been linked to human hereditary lymphedema. Here we show that a...
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