Article
The effect of acetaminophen on ubiquitin homeostasis in Saccharomyces cerevisiae.
PloS one - 1 Jan 2017
Huseinovic Angelina, van Leeuwen Jolanda S, van Welsem Tibor, Stulemeijer Iris, van Leeuwen Fred, Vermeulen Nico P E, Kooter Jan M, Vos J Chris
Abstract excerpt
Acetaminophen (APAP), although considered a safe drug, is one of the major causes of acute liver failure by overdose, and therapeutic chronic use can cause serious health problems. Although the reactive APAP metabolite N-acetyl-p-benzoquinoneimine (NAPQI) is clearly linked to liver toxicity, toxicity of APAP is also found without drug metabolism of APAP to NAPQI. To get more insight into mechanisms of APAP...
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