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Article

The Genomics of Elevated ALT and Adducts in Therapeutic Acetaminophen Treatment: a Pilot Study.

Journal of medical toxicology : official journal of the American College of Medical Toxicology - 1 Apr 2021

Monte Andrew A, Sonn Brandon, Saben Jessica, Rumack Barry H, Reynolds Kate M, Dart Richard C, Heard Kennon J

Abstract excerpt

INTRODUCTION: Therapeutic acetaminophen (APAP) ingestion causes asymptomatic drug-induced liver injury in some patients. In most cases, elevations in alanine aminotransferase (ALT) are transient and return to the normal range, even with continued APAP ingestion, though ALT elevation persists in some patients unpredictably. The etiology of this liver injury or adaption is unclear. Our objective was to identify new...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33051802
DOI: 10.1007/s13181-020-00815-2
PMCID: PMC8017040

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