Article
The Stress-response protein prostate-associated gene 4, interacts with c-Jun and potentiates its transactivation.
Biochimica et biophysica acta - 1 Feb 2014
Rajagopalan Krithika, Qiu Ruoyi, Mooney Steven M, Rao Shweta, Shiraishi Takumi, Sacho Elizabeth, Huang Hongying, Shapiro Ellen, Weninger Keith R, Kulkarni Prakash
Abstract excerpt
The Cancer/Testis Antigen (CTA), Prostate-associated Gene 4 (PAGE4), is a stress-response protein that is upregulated in prostate cancer (PCa) especially in precursor lesions that result from inflammatory stress. In cells under stress, translocation of PAGE4 to mitochondria increases while production of reactive oxygen species decreases. Furthermore, PAGE4 is also upregulated in human fetal prostate, underscoring...
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