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Article

Multiple signals at the extended 8p23 locus are associated with susceptibility to systemic lupus erythematosus.

Journal of medical genetics - 1 Jun 2017

Demirci F Yesim, Wang Xingbin, Morris David L, Feingold Eleanor, Bernatsky Sasha, Pineau Christian, Clarke Ann, Ramsey-Goldman Rosalind, Manzi Susan, Vyse Timothy J, Kamboh M I

Abstract excerpt

BACKGROUND: A major systemic lupus erythematosus (SLE) susceptibility locus lies within a common inversion polymorphism region (encompassing 3.8 - 4.5 Mb) located at 8p23. Initially implicated genes included FAM167A-BLK and XKR6, of which BLK received major attention due to its known role in B-cell biology. Recently, additional SLE risk carried in non-inverted background was also reported. OBJECTIVE AND METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28289186
DOI: 10.1136/jmedgenet-2016-104247
PMCID: PMC5610905

Genes

BLK
XKR6
CLDN23
CTSB
MFHAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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