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Article

The effect of inversion at 8p23 on BLK association with lupus in Caucasian population.

PloS one - 1 Jan 2014

Namjou Bahram, Ni Yizhao, Harley Isaac T W, Chepelev Iouri, Cobb Beth, Kottyan Leah C, Gaffney Patrick M, Guthridge Joel M, Kaufman Kenneth, Harley John B

Abstract excerpt

UNLABELLED: To explore the potential influence of the polymorphic 8p23.1 inversion on known autoimmune susceptibility risk at or near BLK locus, we validated a new bioinformatics method that utilizes SNP data to enable accurate, high-throughput genotyping of the 8p23.1 inversion in a Caucasian population. METHODS: Principal components analysis (PCA) was performed using markers inside the inversion territory...

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Share to Chromosomes, Human, Pair 8
Share to Genetic Loci

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Homozygote

Share to Lupus Erythematosus, Systemic

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Source

Open in PubMed Open full text

Identifiers

PMID: 25545785
DOI: 10.1371/journal.pone.0115614
PMCID: PMC4278715

Genes

BLK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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The effect of inversion at 8p23 on BLK association with lupus in Caucasian population.PMID 25545785Read ↗

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Cosmopolitan inversions have a major impact on trait variation and the power of different GWAS approaches to identify associationsSemantic proximity Read ↗

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