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Regulation of Weibel-Palade Body Exocytosis by α-Synuclein in Endothelial Cells

7 May 2010

Abstract excerpt

alpha-Synuclein is a small presynaptic protein implicated in the pathogenesis of Parkinson disease. Nevertheless, its physiological roles and mechanisms remain incompletely understood. alpha-Synuclein is not only expressed in neurons but also in the vascular endothelium, which contains intracellular granules called Weibel-Palade bodies (WPBs) that contain a number of chemokines, adhesive molecules, and...

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PMID: 20448034
DOI: 10.1074/jbc.m110.103499

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