Article
Resistin up-regulates COX-2 expression via TAK1-IKK-NF-kappaB signaling pathway.
Inflammation - 1 Feb 2010
Zhang Jian, Lei Ting, Chen Xiaodong, Peng Yin, Long Huan, Zhou Lei, Huang Jianfeng, Chen Zhilong, Long Qinqiang, Yang Zaiqing
Abstract excerpt
The hormone resistin, which was originally shown to induce insulin resistance, has been implicated in the regulation of inflammatory processes, but the molecular mechanism underlying such regulation has not been clearly defined. The goal of our study was to determine whether the expression of COX-2 can be induced by resistin and what the potential signaling pathway involved in this process is. Compared with...
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