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Article

Embryonic mosaic deletion of APP results in displaced Reelin-expressing cells in the cerebral cortex

8 Mar 2017

Abstract excerpt

It is widely accepted that amyloid precursor protein (APP) plays a central role in the pathogenesis of Alzheimer's disease. In addition, APP has been proposed to have functions in numerous biological processes including neuronal proliferation, differentiation, migration, axon guidance, and neurite outgrowth, as well as in synapse formation and function. However, germline knockout of APP yields relatively subtle...

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PMID: 28284905
DOI: 10.1016/j.ydbio.2017.03.007

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