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Article

The central fragment of Reelin, generated by proteolytic processing in vivo, is critical to its function during cortical plate development.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 14 Jan 2004

Jossin Yves, Ignatova Nina, Hiesberger Thomas, Herz Joachim, Lambert de Rouvroit Catherine, Goffinet André M

Abstract excerpt

Reelin is a large extracellular protein that controls cortical development. It binds to lipoprotein receptors very-low-density lipoprotein receptor and apolipoprotein-E receptor type 2, thereby inducing phosphorylation of the adapter Dab1. In vivo, Reelin is cleaved into three fragments, but their respective function is unknown. Here we show the following: (1) the central fragment is necessary and sufficient for...

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Source

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Identifiers

PMID: 14724251
DOI: 10.1523/JNEUROSCI.3408-03.2004
PMCID: PMC6730001

Genes

CNR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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