Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 Jul 2010

Kocherhans Samira, Madhusudan Amrita, Doehner Jana, Breu Karin S, Nitsch Roger M, Fritschy Jean-Marc, Knuesel Irene

Abstract excerpt

In addition to the fundamental role of the extracellular glycoprotein Reelin in neuronal development and adult synaptic plasticity, alterations in Reelin-mediated signaling have been suggested to contribute to neuronal dysfunction associated with Alzheimer's disease (AD). In vitro data revealed a biochemical link between Reelin-mediated signaling, Tau phosphorylation, and amyloid precursor protein (APP)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Adhesion Molecules, Neuronal

Share to Extracellular Matrix Proteins

Share to Neurofibrillary Tangles

Share to Plaque, Amyloid

Share to Reelin Protein

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 20610758
DOI: 10.1523/JNEUROSCI.0418-10.2010
PMCID: PMC6632461

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice.PMID 20610758Read ↗

Reelin in plaques of β-amyloid precursor protein and presenilin-1 double-transgenic miceSemantic proximity Read ↗

The β-amyloid peptide compromises Reelin signaling in Alzheimer's disease.Semantic proximity Read ↗

The Role of Reelin Signaling in Alzheimer’s DiseaseSemantic proximity Read ↗

Reelin-immunoreactivity in the hippocampal formation of 9-month-old wildtype mouse: effects of APP/PS1 genotype and ovariectomy.Semantic proximity Read ↗

Reelin links Apolipoprotein E4, Tau, and Amyloid‐β in Alzheimer’s diseaseSemantic proximity Read ↗

Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study.Semantic proximity Read ↗

Decreased generation of C‐terminal fragments of ApoER2 and increased reelin expression in Alzheimer's diseaseSemantic proximity Read ↗

Impaired Src signaling and post-synaptic actin polymerization in Alzheimer's disease mice hippocampus--linking NMDA receptors and the reelin pathway.Semantic proximity Read ↗

Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice.Semantic proximity Read ↗

F-spondin gene transfer improves memory performance and reduces amyloid-β levels in mice.Semantic proximity Read ↗

p75NTR regulates Abeta deposition by increasing Abeta production but inhibiting Abeta aggregation with its extracellular domain.Semantic proximity Read ↗

Embryonic mosaic deletion of APP results in displaced Reelin-expressing cells in the cerebral cortexSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.