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Article

Charge inversion at position 68 of the glucagon and glucagon-like peptide-1 receptors supports selectivity in hormone action.

Journal of peptide science : an official publication of the European Peptide Society - 1 Mar 2011

Day Jonathan W, Li Pengyun, Patterson James T, Chabenne Joe, Chabenne Maria Dimarchi, Gelfanov Vasily M, Dimarchi Richard D

Abstract excerpt

Glucagon and glucagon-like peptide-1 (GLP-1)are two structurally related hormones that acutely regulate glucose control in opposite directions through homologous receptors. The molecular basis for selectivity between these two hormones and their receptors is of physiological and medicinal importance. The application of co-agonists to enhance body weight reduction and correct multiple abnormalities associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21308878
DOI: 10.1002/psc.1317

Genes

GCGR
GIPR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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