Article
The pharmacogenetics of CYP2C9 and CYP2C19: ethnic variation and clinical significance.
Current clinical pharmacology - 1 Jan 2007
Rosemary J, Adithan C
Abstract excerpt
CYP2C9 and CYP2C19 are important drug metabolizing enzymes and together metabolize about 18% of currently available drugs. Some of the important groups of drugs that are metabolized by them are antihypertensives, hypoglycemics, anticonvulsants, antiulcer drugs etc. Genes encoding these enzymes are polymorphically expressed. Thirty variant alleles for CYP2C9 and 21 for CYP2C19 have been reported. The frequencies...
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