Article
Heterarchy of transcription factors driving basal and luminal cell phenotypes in human urothelium.
Cell death and differentiation - 1 May 2017
Fishwick Carl, Higgins Janet, Percival-Alwyn Lawrence, Hustler Arianna, Pearson Joanna, Bastkowski Sarah, Moxon Simon, Swarbreck David, Greenman Chris D, Southgate Jennifer
Abstract excerpt
Cell differentiation is affected by complex networks of transcription factors that co-ordinate re-organisation of the chromatin landscape. The hierarchies of these relationships can be difficult to dissect. During in vitro differentiation of normal human uro-epithelial cells, formaldehyde-assisted isolation of regulatory elements (FAIRE-seq) and RNA-seq was used to identify alterations in chromatin accessibility...
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