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Subtype-associated epigenomic landscape and 3D genome structure in bladder cancer

15 Apr 2021

Abstract excerpt

Muscle-invasive bladder cancers are characterized by their distinct expression of luminal and basal genes, which could be used to predict key clinical features such as disease progression and overall survival. Transcriptionally, FOXA1, GATA3, and PPARG are shown to be essential for luminal subtype-specific gene regulation and subtype switching, while TP63, STAT3, and TFAP2 family members are critical for...

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 33858483
DOI: 10.1186/s13059-021-02325-y

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