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Article

Farnesylation of pex19p is required for its structural integrity and function in peroxisome biogenesis.

The Journal of biological chemistry - 31 Jul 2009

Rucktäschel Robert, Thoms Sven, Sidorovitch Vadim, Halbach Andre, Pechlivanis Markos, Volkmer Rudolf, Alexandrov Kirill, Kuhlmann Jürgen, Rottensteiner Hanspeter, Erdmann Ralf

Abstract excerpt

The conserved CaaX box peroxin Pex19p is known to be modified by farnesylation. The possible involvement of this lipid modification in peroxisome biogenesis, the degree to which Pex19p is farnesylated, and its molecular function are unknown or controversial. We resolve these issues by first showing that the complete pool of Pex19p is processed by farnesyltransferase in vivo and that this modification is...

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Identifiers

PMID: 19451657
DOI: 10.1074/jbc.M109.016584
PMCID: PMC2742854

Genes

PEX19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Farnesylation of pex19p is required for its structural integrity and function in peroxisome biogenesis.PMID 19451657Read ↗

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