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Article

Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19.

The EMBO journal - 18 Mar 2009

Neufeld Christian, Filipp Fabian V, Simon Bernd, Neuhaus Alexander, Schüller Nicole, David Christine, Kooshapur Hamed, Madl Tobias, Erdmann Ralf, Schliebs Wolfgang, Wilmanns Matthias, Sattler Michael

Abstract excerpt

Protein import into peroxisomes depends on a complex and dynamic network of protein-protein interactions. Pex14 is a central component of the peroxisomal import machinery and binds the soluble receptors Pex5 and Pex19, which have important function in the assembly of peroxisome matrix and membrane, respectively. We show that the N-terminal domain of Pex14, Pex14(N), adopts a three-helical fold. Pex5 and Pex19...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19197237
DOI: 10.1038/emboj.2009.7
PMCID: PMC2666029

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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