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Article

Evidence for adaptive evolution in the receptor-binding domain of seasonal coronaviruses OC43 and 229e

18 Jan 2021

Abstract excerpt

Seasonal coronaviruses (OC43, 229E, NL63, and HKU1) are endemic to the human population, regularly infecting and reinfecting humans while typically causing asymptomatic to mild respiratory infections. It is not known to what extent reinfection by these viruses is due to waning immune memory or antigenic drift of the viruses. Here we address the influence of antigenic drift on immune evasion of seasonal...

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PMID: 33463525
DOI: 10.7554/elife.64509

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